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Chronic pelvic and related genital pain in transgender and gender-diverse people: a scoping review

درد مزمن لگنی و دردهای تناسلی مرتبط در افراد ترنسجندر و دارای تنوع جنسیتی: یک مرور محدوده‌ای

Ragav Chona, Sami G. Sabbah, Marina F Englesakis, Tania Di Renna, Olivia Drodge, Brittany N. Rosenbloom, Mathew Leonardi, Gianni R. Lorello

EClinicalMedicine 2026 Vol. 101, pp. 104252
https://doi.org/10.1016/j.eclinm.2026.104252

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چکیده

Background Chronic pelvic pain (CPP) and related genital pain are disabling and multifaceted, but understudied in transgender and gender-diverse (TGD) people. Methods In this scoping review, we mapped evidence on prevalence, aetiology, assessment, and management across gender-affirming hormone therapy (GAHT), surgical, and community contexts. Following Joanna Briggs Institute methodology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) reporting guidance, we searched ten databases from database inception to 30 July 2025, supplemented by citation chasing, and including primary-data reports of duration-defined CPP (persistent or recurrent pelvic pain for at least three months) or related pelvic and genital pain within a broad chronic pain framework. The search protocol was registered prospectively on the Open Science Framework (osf.io/mk6cp). Two reviewers independently screened records and extracted published data. Findings 24 reports representing 23 unique cohorts and 5527 TGD participants were included. Only one study explicitly estimated duration-defined CPP prevalence, reporting 17·7% among TGD adults assigned female at birth. Broader pelvic and genital pain outcomes ranged from 9·6% to 72·2% across five studies, but should not be interpreted as duration-defined CPP prevalence. Four non-mutually exclusive domains were identified: hormonal and tissue-mediated, pelvic floor and musculoskeletal, surgical and anatomical, and psychosocial and trauma-related. Assessment and diagnostic pathways were heterogeneous. Management evidence was very limited and derived almost entirely from observational studies, programme audits, and case reports; only one short randomised trial evaluated an intervention. Interpretation Our findings support gender-affirming, multidisciplinary evaluation while highlighting the need for standardised CPP definitions, validated TGD-specific patient-reported measures, prospective cohorts, and adequately powered interventional trials. Funding None.

چکیده به فارسی

زمینه و هدف: درد مزمن لگنی (CPP) و دردهای تناسلی مرتبط، ناتوان‌کننده و چندوجهی هستند، اما در افراد ترنسجندر و دارای تنوع جنسیتی (TGD) کمتر مورد مطالعه قرار گرفته‌اند. روش‌ها: در این مرور محدوده‌ای، شواهد مربوط به شیوع، علل، ارزیابی و مدیریت در زمینه‌های هورمون‌درمانی تأییدکننده جنسیت (GAHT)، جراحی و جامعه را بررسی کردیم. با پیروی از روش‌شناسی مؤسسه Joanna Briggs و راهنمای گزارش‌دهی PRISMA-ScR، ده پایگاه داده از ابتدای تأسیس تا ۳۰ ژوئیه ۲۰۲۵ جستجو شد و جستجوی ارجاعات نیز انجام گرفت. گزارش‌های داده‌های اولیه درباره CPP با تعریف مدت‌زمان (درد لگنی مداوم یا عودکننده به مدت حداقل سه ماه) یا دردهای لگنی و تناسلی مرتبط در چارچوب گسترده درد مزمن وارد شدند. پروتکل جستجو به طور پیشینی در Open Science Framework (osf.io/mk6cp) ثبت شد. دو مرورگر به طور مستقل منابع را غربالگری و داده‌های منتشرشده را استخراج کردند. یافته‌ها: ۲۴ گزارش نمایانگر ۲۳ گروه منحصربه‌فرد و ۵۵۲۷ شرکت‌کننده TGD وارد مطالعه شدند. تنها یک مطالعه به طور صریح شیوع CPP با تعریف مدت‌زمان را برآورد کرد و میزان ۱۷/۷٪ را در بزرگسالان TGD با تعیین جنسیت مؤنث در بدو تولد گزارش داد. پیامدهای گسترده‌تر درد لگنی و تناسلی در پنج مطالعه بین ۹/۶٪ تا ۷۲/۲٪ متغیر بود، اما نباید به عنوان شیوع CPP با تعریف مدت‌زمان تفسیر شود. چهار حوزه غیرانحصاری شناسایی شد: هورمونی و بافتی، کف لگن و اسکلتی‌عضلانی، جراحی و آناتومیکی، و روانی‌اجتماعی و مرتبط با تروما. مسیرهای ارزیابی و تشخیصی ناهمگون بودند. شواهد مربوط به مدیریت بسیار محدود و تقریباً به طور کامل برگرفته از مطالعات مشاهده‌ای، ارزیابی برنامه‌ها و گزارش‌های موردی بود؛ تنها یک کارآزمایی تصادفی کوتاه یک مداخله را ارزیابی کرد. تفسیر: یافته‌های ما از ارزیابی چندرشته‌ای و تأییدکننده جنسیت حمایت می‌کند و در عین حال بر نیاز به تعاریف استاندارد CPP، ابزارهای معتبر گزارش‌شده توسط بیماران ویژه TGD، گروه‌های کوهورت آینده‌نگر و کارآزمایی‌های مداخله‌ای با توان کافی تأکید دارد. حمایت مالی: ندارد.

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موضوع‌ها و کلیدواژه‌ها

جراحیدرددرمانchronic pelvic paingender-affirming hormone therapygender-diverse peoplegenital paintransgender people

ارجاع

Chona, R., Sabbah, S. G., Englesakis, M. F., Renna, T. D., Drodge, O., Rosenbloom, B. N., Leonardi, M., & Lorello, G. R. (2026). Chronic pelvic and related genital pain in transgender and gender-diverse people: a scoping review. EClinicalMedicine, 101, 104252. https://doi.org/10.1016/j.eclinm.2026.104252

(Chona et al., 2026)

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  1. با احترام و بدون توهین، تحقیر، برچسب‌زنی یا حمله‌ی شخصی با دیگران گفتگو کنید.
  2. از نوشتن هرگونه اطلاعات هویتی یا قابل‌شناسایی مراجعان، بیماران یا اشخاص ثالث، از جمله نام، شماره‌ی تماس، تصویر، نشانی، محل کار یا جزئیات منحصربه‌فرد پرونده خودداری کنید.
  3. اگر درباره‌ی یک تجربه‌ی بالینی سؤال می‌کنید، اطلاعات را تا حد ممکن بی‌نام و کلی بیان کنید تا امکان شناسایی فرد وجود نداشته باشد.
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  6. انتشار تبلیغات، معرفی خدمات شخصی، شماره‌ی تلفن، شناسه‌ی شبکه‌های اجتماعی، پیوند تبلیغاتی یا درخواست جذب مراجع در این بخش مجاز نیست.
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چکیده

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چکیده

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