The involvement of oxytocin in social behavior is well established, yet its interaction with neuromodulatory systems, such as serotonin and dopamine, remains incompletely understood. Here, we utilized immunohistochemistry, anatomical tracing, chemogenetic, and ex vivo electrophysiological approaches primarily in male mice, with female mice used only for an additional anatomical tracing control experiment, investigate how oxytocin modulates serotonergic and dopaminergic neuronal populations. Employing the dual-eGRASP tool, we visualized oxytocinergic projections from the paraventricular nucleus (PVN) to the serotonergic and dopaminergic neurons in dorsal raphe nucleus (DRN). Blocking oxytocin receptors in the DRN attenuated social interaction behavior. Additionally, analysis of c-Fos levels and neuronal excitability revealed that oxytocin inhibits serotonergic neurons while activating dopaminergic neurons in the DRN. Our findings suggest a bidirectional regulatory role of oxytocin signaling in the DRN serotonergic and dopaminergic neurons. Significance Statement Social behavior relies on interactions among neuromodulatory systems, yet how oxytocin communicates with serotonin and dopamine circuits remains unclear. We identify the DRN as a functionally relevant target of hypothalamic oxytocin neurons during social approach. Using dual-eGRASP, we visualize contacts from PVN oxytocin neurons onto both serotonergic and dopaminergic DRN. Blocking oxytocin receptors in the DRN reduces social interaction without affecting locomotion. Moreover, oxytocin suppresses serotonergic neuronal activity while increasing dopaminergic neuronal activation, revealing opposing control of two prosocial neuromodulatory populations within the same region. These findings provide a circuit framework for how oxytocin coordinates social behavior through bidirectional modulation of dorsal raphe neuromodulators.
چکیده به فارسی
نقش اکسیتوسین در رفتار اجتماعی بهخوبی اثبات شده است، اما تعامل آن با سیستمهای نوروماژولاتوری مانند سروتونین و دوپامین هنوز بهطور کامل درک نشده است. در این پژوهش، با استفاده از روشهای ایمنوهیستوشیمی، ردیابی آناتومیکی، شیمیژنتیک و الکتروفیزیولوژی خارجزنده عمدتاً در موشهای نر و استفاده از موشهای ماده صرفاً برای آزمایش کنترل ردیابی آناتومیکی اضافی، بررسی کردیم که اکسیتوسین چگونه جمعیتهای نورونی سروتونرژیک و دوپامینرژیک را تعدیل میکند. با بهکارگیری ابزار dual-eGRASP، پروجکشنهای اکسیتوسینرژیک از هسته پاراونتریکولار (PVN) به نورونهای سروتونرژیک و دوپامینرژیک در هسته رافه پشتی (DRN) را مشاهده کردیم. مسدودسازی گیرندههای اکسیتوسین در DRN رفتار تعامل اجتماعی را کاهش داد. همچنین، تحلیل سطوح c-Fos و تحریکپذیری نورونی نشان داد که اکسیتوسین نورونهای سروتونرژیک را مهار و نورونهای دوپامینرژیک را در DRN فعال میکند. یافتههای ما نقش تنظیمی دوسویه سیگنالدهی اکسیتوسین در نورونهای سروتونرژیک و دوپامینرژیک DRN را پیشنهاد میکند. بیان اهمیت: رفتار اجتماعی مبتنی بر تعامل میان سیستمهای نوروماژولاتوری است، اما نحوه ارتباط اکسیتوسین با مدارهای سروتونین و دوپامین همچنان نامشخص است. ما DRN را بهعنوان هدف عملکردی نورونهای اکسیتوسین هیپوتالاموس در رویکرد اجتماعی شناسایی کردیم. با استفاده از dual-eGRASP، تماسهای نورونهای اکسیتوسین PVN با هر دو جمعیت سروتونرژیک و دوپامینرژیک DRN را مشاهده کردیم. مسدودسازی گیرندههای اکسیتوسین در DRN تعامل اجتماعی را بدون تأثیر بر حرکت کاهش میدهد. افزون بر این، اکسیتوسین فعالیت نورونهای سروتونرژیک را سرکوب و فعالیت نورونهای دوپامینرژیک را افزایش میدهد و کنترل متضاد دو جمعیت نوروماژولاتوری طرفدار اجتماع را در یک ناحیه نشان میدهد. این یافتهها چارچوبی مداری برای چگونگی هماهنگی رفتار اجتماعی توسط اکسیتوسین از طریق تعدیل دوسویه نوروماژولاتورهای هسته رافه پشتی ارائه میکند.
ترجمهی خودکار برای آشنایی سریع؛ برای نقل و ارجاع، متن اصلی ملاک است.
Choi, J. E., Kim, Y. K., Sung, Y., Choi, D. I., Kim, J., Lee, C., Lee, J., Yu, N., Choe, H. K., & Kaang, B. (2026). Oxytocin signaling bidirectionally modulates serotonergic and dopaminergic neurons in the dorsal raphe nucleus. eNeuro, ENEURO.0182–26.2026. https://doi.org/10.1523/eneuro.0182-26.2026
با احترام و بدون توهین، تحقیر، برچسبزنی یا حملهی شخصی با دیگران گفتگو کنید.
از نوشتن هرگونه اطلاعات هویتی یا قابلشناسایی مراجعان، بیماران یا اشخاص ثالث، از جمله نام، شمارهی تماس، تصویر، نشانی، محل کار یا جزئیات منحصربهفرد پرونده خودداری کنید.
اگر دربارهی یک تجربهی بالینی سؤال میکنید، اطلاعات را تا حد ممکن بینام و کلی بیان کنید تا امکان شناسایی فرد وجود نداشته باشد.
این بخش برای یادگیری و گفتوگوی علمی است و جایگزین ارزیابی، تشخیص، مشاوره یا رواندرمانی شخصی نیست.
در شرایط بحران یا خطر آسیب به خود یا دیگران، به این بخش اتکا نکنید و برای دریافت کمک فوری با اورژانس اجتماعی ۱۲۳ یا صدای مشاور بهزیستی ۱۴۸۰ تماس بگیرید.
انتشار تبلیغات، معرفی خدمات شخصی، شمارهی تلفن، شناسهی شبکههای اجتماعی، پیوند تبلیغاتی یا درخواست جذب مراجع در این بخش مجاز نیست.
در بیان ادعاهای علمی، بهویژه دربارهی اثربخشی درمانها، تشخیص یا یافتههای پژوهشی، تا حد امکان نام منبع معتبر، مقاله یا راهنمای علمی را ذکر کنید.
از ارائهی تشخیص قطعی، تجویز درمان یا دارو و توصیههای بالینی شخصی به سایر کاربران خودداری کنید.
پاسخهایی که کارشناسان فکر بنیان میدهند با برچسب «پاسخ فکر بنیان» یا «کارشناس فکر بنیان» نمایش داده میشوند و سایر نوشتهها بیانگر نظر کاربران هستند.
گزارش نوشتهی نامناسب: اگر نوشتهای حاوی نقض محرمانگی، محتوای آسیبزا، توهین، تبلیغ یا تخلف از این قوانین است، گزینهی «گزارش» را انتخاب کنید تا تیم سایت بررسی کند.
Background: Awareness of youth-friendly sexual and reproductive health services (YFSRHS) is an important starting point for enabling young people to identify and seek appropriate sexual and reproductive health information and care. However, awareness of these services may vary across settings, including higher education institutions. Objective: To determine the level of awareness of YFSRHS among undergraduate students at Saint Augustine University of Tanzania (SAUT), Malimbe Campus. Methods: A quantitative descriptive cross-sectional study was conducted among undergraduate students at SAUT Malimbe Campus. Data were collected using a structured, self-administered questionnaire. Of 109 questionnaires distributed, 108 completed questionnaires were included in the analysis. Descriptive statistics were used to summarize students’ awareness and reported sources of information. Results: Of the 108 respondents, 96 (88.9%) reported having heard of YFSRHS, while 12 (11.1%) had not. Social media was the most frequently reported source of information (44.0%), followed by friends or peers (41.0%) and health facilities (36.0%). University programmes and posters or advertisements were reported less frequently. Conclusion: Most respondents had heard of YFSRHS, with social media and peer networks serving as prominent information channels. Strengthening accurate information through these channels, alongside university-based communication, may help address the awareness gap among students who remain unreached.
Over the last decade, there has been a visible surge of students participating in and leading different forms of activism. Following the cultural reckoning of 2020, the United States saw a rise in awareness and engagement in activism among young individuals. Continuing this trend, higher education institutions have seen an increase in on-campus demonstrations in recent years. Given the recent increase in activism, political engagement, and the globalization of social issues, this study examined how attitudes, beliefs, individual factors, and prior behaviors relate to undergraduate students’ willingness to engage in different forms of activism (i.e., conventional and high-risk). Across both forms of activism, institutional advocacy (i.e., the behavioral targeting of institutional racism) was the most consistent unique predictor of a student's willingness to engage in activism. Need for cognition and individual advocacy were significantly and positively related to conventional activism, whereas political orientation was negatively related to it. Social justice orientation was significantly and negatively related to high-risk activism.
Social capital represents a relational resource developed through trust, professional networks, collaboration, peer support, and knowledge exchange. In the context of Social Studies Education, social capital can support teachers in accessing information, experiences, and professional resources relevant to professional development and instructional planning. This study aims to analyze the conceptualization of teachers’ social capital, identify its dimensions in relation to teacher professionalism, and examine its relevance to Social Studies teaching practices and instructional planning. The study employs a Systematic Literature Review (SLR) approach guided by the PRISMA 2020 framework. The literature analyzed consists of scholarly publications published between 2023 and 2026 in Indonesian and English that met the established inclusion criteria. The data were analyzed through thematic synthesis based on conceptual dimensions, forms of professional relationships, and their contributions to teaching practices. The synthesis indicates that social capital facilitates teachers’ access to information, experiences, feedback, and professional support through networks and collaborative relationships. These resources can strengthen professional learning and pedagogical decision-making relevant to Social Studies instructional planning. However, empirical evidence directly linking teachers’ social capital to the quality of Social Studies instructional planning remains limited. These findings highlight the need for further research on how social capital can be translated into improvements in the quality of Social Studies instructional planning components.
Children's behaviour and social adjustment within the classroom are important considerations. Behaviour can refer to how a pupil engages with learning tasks, follows instructions, works with others and interacts within the classroom. Social adjustment can relate to how children feel they fit in, build friendships, communicate effectively and feel included. Although behaviour and social adjustment are two distinct areas, they will be influenced by each other. This conceptual article will discuss the relationship between behaviour and social adjustment for upper primary school students. Using theories such as ecological systems, social learning and sociocultural. School engagement, friendships and school belonging will also be discussed. It is important to consider how behaviour should be seen as more than just an individual trait. Family factors, teaching style, peer relationships, individual differences and school factors can influence how a pupil behaves. A strength based approach to children's behaviour and social adjustment will be advocated. The article will conclude with key implications for classroom settings and recommendations for future research. Future research should be culturally aware, developmentally appropriate and ethical. This article is theoretical and will not give any findings.
Religious education is often expected to promote tolerance, but respect for religious difference does not necessarily ensure accurate understanding of religious others. This study examines how religious education policies in Indonesia and England emphasize different forms of cognitive tolerance. Using qualitative document analysis and comparative policy analysis, the study analyzes selected legal, curricular, and pedagogical documents through four components: Knowledge of Religious Others, Recognition of Internal Diversity, Critical Reflection, and Understanding Commonalities and Differences. Indonesian policy gives greater relative emphasis to understanding commonalities and differences within religion-specific formation, social harmony, and responsible citizenship. English policy gives greater emphasis to critical reflection and knowledge of religious and non-religious worldviews through shared enquiry. Recognition of Internal Diversity appears in similar proportions in both datasets, but it serves different curricular functions. The findings show differently configured pathways toward cognitive tolerance, combining the same cognitive components with different relative emphases and curricular purposes.