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brain development

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Kansas City Brain Builders: associations between a multisectoral community language nutrition intervention and change in practices and growth in child language over two years

Charles R. Greenwood; Gabriela Guerrero; Alana G. Schnitz; Sandra Cintora; Christine Giancola; Judith J. Carta Frontiers in Public Health, 2026, Vol. 14, pp. 1986929 https://doi.org/10.3389/fpubh.2026.1986929

چکیده

Background and objectives Health literacy in adulthood plays a major role in an individual’s ability to use health information to benefit their health. Social determinants in early childhood initiate the development of health literacy through newborn brain development and oral language acquisition. Both of these processes are promoted by stimulation from everyday interactions with parents/caregivers at home and in the community. Unequal access to language-learning opportunities during early childhood represents a modifiable developmental and social determinant of later educational and health outcomes. There are inequities in these time-sensitive interactions—specifically language-learning opportunities—across families in the population, which are social determinants of early literacy, achievement in school, and later-life education, health, and economic and social well-being across the life span. This gap is most pronounced among children who grow up in poverty in the United States and internationally. The healthcare system in the United States effectively reaches to nearly all infants; however, language-learning opportunities are not a focus during well-child visits. The term “Language Nutrition” (LN) was coined in prior research to refer to these developmentally rich interactions known to support brain and language growth in children younger than preschool age. We developed Kansas City Brain Builders (KCBB) to address this inequity by promoting LN broadly among families and children in a community so that all children have a more equitable home language environment. The purpose of this study is to report longitudinal empirical findings on families and children related to the implementation of KCBB, a public health approach to community change, over 2 years. Methods The evaluation involved two parallel longitudinal studies: the Community study and the Family study. The Community study assessed the implementation of a KCBB multisectoral community partnership to promote LN-friendly changes in local programs, practices, and policies. The Family study involved longitudinal assessments of a sample of 83 English- and Spanish-speaking families with children younger than 36 months of age, evaluating the KCBB impacts on parental behaviors and child growth in language skills. Results KCBB led to a high level of documented program implementation and substantial LN promotion throughout the community. Repeated parent assessments indicated that participants had received LN messages from multiple community sectors over time, increased their knowledge of the importance of LN, and used LN through storybook reading, verbal responsiveness, and teaching behaviors during interactions with their children. Growth in children’s early language skills was significantly associated with the amount of LN they received. Discussion/Conclusion KCBB is one of the few multisectoral interventions designed to promote community-wide change targeting LN. It is a manualized intervention that can be replicated by other communities. This study employed three levels of measurement such that change could be evaluated in a theoretical framework of influence from community engagement to parental behavior and growth in child language skills. Findings provide preliminary evidence that a multisectoral community approach can achieve broad reach and is associated with changes in caregiver practices and child language growth. Larger, controlled, and replicated studies are needed to establish causal effects and determine whether such approaches reduce disparities in language-learning opportunities.

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Minor Physical Anomalies and Neurological Soft Signs Mark Poor Insight in Obsessive–Compulsive Disorder

ناهنجاری‌های جزئی جسمی و نشانه‌های نرم عصبی، بینش ضعیف را در اختلال وسواس فکری-عملی نشان‌گذاری می‌کنند

Beyza Zeynep Seçkin; Muhammed Emin Boylu; İsmet Kırpınar Clinical Psychopharmacology and Neuroscience, 2026, pp. 1-00 https://doi.org/10.9758/cpn.26.1478

چکیده

Objective: Poor insight in obsessive-compulsive disorder (OCD) has been proposed to reflect a more neurodevelopmentally rooted subtype.We examined whether minor physical anomalies (MPAs) and neurological soft signs (NSS), two peripheral markers of aberrant neurodevelopment, distinguish OCD patients according to insight.Methods: Sixty-seven adults with Diagnostic and Statistical Manual of Mental Disorders, fifth edition OCD were assessed with the Yale-Brown Obsessive Compulsive Scale, the Brown Assessment of Beliefs Scale (BABS), the Schedule for the Assessment of Insight, the Waldrop MPA scale and the Neurological Evaluation Scale.Patients were classified as having good (BABS ≤ 12; n = 37) or poor (BABS ≥ 13; n = 30) insight.Firth penalized logistic regression identified independent predictors.Results: The groups were comparable in age, sex, marital status, employment and comorbidity, whereas poor insight was associated with lower education, past suicidal behaviour and greater symptom severity.Total, craniofacial and peripheral MPA scores were higher in the poor-insight group, with an excess of ocular, auricular and oral anomalies.Low-set ears, epicanthus and high-arched palate were the most discriminating.Total NSS and all subdomains except complex motor sequencing were approximately doubled, with large effects for sensory integration and motor coordination.MPA burden predicted poor insight independently of symptom severity, while NSS was the dominant predictor when severity was excluded (apparent area under the receiver operating characteristic curve 0.97; optimism-corrected 0.95).Conclusion: These convergent findings suggest a neurodevelopmental pattern in poor-insight OCD.Given the cross-sectional design, modest sample and absence of a control group, they should be regarded as hypothesis-generating.

هدف: بینش ضعیف در اختلال وسواس فکری-عملی (OCD) به عنوان بازتاب یک زیرگونه با ریشه‌های عصب‌رشدی بیشتر پیشنهاد شده است. ما بررسی کردیم که آیا ناهنجاری‌های جزئی جسمی (MPAs) و نشانه‌های نرم عصبی (NSS)، دو شاخص محیطی رشد عصبی غیرطبیعی، بیماران OCD را بر اساس بینش متمایز می‌کنند یا خیر. روش‌ها: شصت‌وهفت بزرگسال مبتلا به اختلال وسواس فکری-عملی بر اساس ویرایش پنجم راهنمای تشخیصی و آماری اختلالات روانی (DSM-5) با مقیاس وسواس فکری-عملی ییل-براون، مقیاس ارزیابی باورهای براون (BABS)، برنامه ارزیابی بینش، مقیاس MPA والدروپ و مقیاس ارزیابی عصبی مورد ارزیابی قرار گرفتند. بیماران بر اساس بینش خوب (BABS ≤ 12؛ n = 37) یا ضعیف (BABS ≥ 13؛ n = 30) طبقه‌بندی شدند. رگرسیون لجستیک پنالتی‌شده Firth پیش‌بینی‌کننده‌های مستقل را شناسایی کرد. نتایج: گروه‌ها از نظر سن، جنس، وضعیت تأهل، اشتغال و همبودی قابل مقایسه بودند، در حالی که بینش ضعیف با تحصیلات پایین‌تر، رفتار خودکشی قبلی و شدت بیشتر علائم همراه بود. امتیاز کل، کرانیوفاسیال و محیطی MPA در گروه با بینش ضعیف بالاتر بود و فراوانی بیشتری از ناهنجاری‌های چشمی، گوشی و دهانی مشاهده شد. گوش‌های پایین‌نشسته، اپی‌کانتوس و کام قوسی‌شکل بالا بیشترین قدرت تمایز را داشتند. امتیاز کل NSS و همه زیرحوزه‌ها به جز توالی حرکتی پیچیده تقریباً دو برابر بود و اثرات بزرگی برای یکپارچگی حسی و هماهنگی حرکتی مشاهده شد. بار MPA به طور مستقل از شدت علائم، بینش ضعیف را پیش‌بینی کرد، در حالی که NSS پیش‌بینی‌کننده غالب بود زمانی که شدت علائم حذف شد (مساحت زیر منحنی مشخصه عملکرد گیرنده آشکار 0.97؛ تصحیح‌شده با خوش‌بینی 0.95). نتیجه‌گیری: این یافته‌های همگرا الگوی عصب‌رشدی را در OCD با بینش ضعیف پیشنهاد می‌کنند. با توجه به طراحی مقطعی، حجم نمونه متوسط و نبود گروه کنترل، این نتایج باید فرضیه‌ساز تلقی شوند.

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