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Adverse childhood experiences are linked to pre-pregnancy stressful life events across generations

تجارب نامطلوب دوران کودکی با رویدادهای پراسترس زندگی پیش از بارداری در نسل‌های مختلف مرتبط است

Huafei Yang, Zifan Zhang, Weijie Ding, Hui Wang, Yue Zhang, Yangyang Cheng, Jiyue Dai, Yue Liu, Sunyi Wang, Yaguan Zhou, Hongyu Cai, Yipei Zhao, Xiaona Liu, Shuying Zhang, Zhiran Guo, Xiaoqin Zhu, Chenkai Wu

Communications Medicine 2026
https://doi.org/10.1038/s43856-026-01931-w

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چکیده

Adverse childhood experiences (ACEs) shape the lifecourse psychosocial well-being, yet evidence linking ACEs to pre-pregnancy stressful life events (pre-PSLEs) across generations remains limited. This study examined the associations between ACEs and pre-PSLEs across two generations of women and explored pathways of intergenerational stress transmission. A total of 2,235 mother-offspring pairs were obtained from the Grandmothers, Mothers, and Their Children’s Health study. Maternal and offspring ACEs were assessed using the Childhood Trauma Screener. Offspring pre-PSLEs included conflict with partners, conflict with family members, physical/sexual/emotional abuse, deaths of friends or relatives, and financial stress. We used multivariable logistic regression to examine associations between ACEs and pre-PSLEs, and structural equation modeling to explore mediation by offspring ACEs. Overall, 18.17% of mothers and 14.27% of offspring report ACEs; 29.49% of offspring report pre-PSLEs. Both maternal (OR = 1.79, 95% CI: 1.41–2.27) and offspring ACEs (OR = 2.23, 95% CI: 1.73–2.89) significantly increase the odds of offspring pre-PSLEs, showing dose–response relationships. These patterns persist across all ACE subtypes. Offspring ACEs mediate 79.64% of the association between maternal ACEs and offspring pre-PSLEs. ACEs are associated with pre-PSLEs both within and across generations, suggesting a pathway of stress transmission from early life into adulthood. These findings highlight the importance of early identification and intervention for ACEs within pre-pregnancy health management. Difficult childhood experiences, such as abuse or neglect, can affect health and wellbeing throughout life. We investigated whether these experiences, known as adverse childhood experiences (ACEs), are associated with stressful life events (SLEs) before pregnancy and whether a mother’s childhood adversity is linked to her daughter’s stress before pregnancy. We studied 2,235 mother–daughter pairs in China. Mothers and daughters reported their childhood experiences, and daughters also reported SLEs during the year before pregnancy. We found that both maternal and offspring ACEs were associated with greater pre-pregnancy stress. Most of the association between maternal ACEs and daughters’ pre-pregnancy stress was explained by daughters’ own ACEs. These findings highlight the importance of identifying and supporting women with childhood adversity before pregnancy to improve maternal and child health.

چکیده به فارسی

تجارب نامطلوب دوران کودکی (ACEs) بهزیستی روانی-اجتماعی در طول زندگی را شکل می‌دهند، اما شواهد مربوط به ارتباط ACEs با رویدادهای پراسترس زندگی پیش از بارداری (pre-PSLEs) در نسل‌های مختلف هنوز محدود است. این مطالعه ارتباط بین ACEs و pre-PSLEs را در دو نسل از زنان بررسی کرده و مسیرهای انتقال استرس بین‌نسلی را مورد کاوش قرار داده است. در مجموع، ۲٬۲۳۵ جفت مادر-فرزند از مطالعه سلامت مادربزرگ‌ها، مادران و فرزندان آن‌ها انتخاب شدند. ACEs مادران و فرزندان با استفاده از Childhood Trauma Screener ارزیابی شد. pre-PSLEs فرزندان شامل تعارض با شریک زندگی، تعارض با اعضای خانواده، سوءاستفاده جسمی/جنسی/عاطفی، مرگ دوستان یا بستگان و استرس مالی بود. برای بررسی ارتباط بین ACEs و pre-PSLEs از رگرسیون لجستیک چندمتغیره و برای بررسی میانجی‌گری توسط ACEs فرزندان از مدل‌سازی معادلات ساختاری استفاده شد. به طور کلی، ۱۸/۱۷٪ از مادران و ۱۴/۲۷٪ از فرزندان گزارش‌دهنده ACEs بودند؛ ۲۹/۴۹٪ از فرزندان pre-PSLEs را گزارش کردند. هم ACEs مادران (OR = 1.79, 95% CI: 1.41–2.27) و هم ACEs فرزندان (OR = 2.23, 95% CI: 1.73–2.89) به طور معناداری احتمال pre-PSLEs فرزندان را افزایش می‌دهند و رابطه دوز-پاسخ را نشان می‌دهند. این الگوها در تمام زیرگروه‌های ACEs پایدار باقی می‌ماند. ACEs فرزندان ۷۹/۶۴٪ از ارتباط بین ACEs مادران و pre-PSLEs فرزندان را میانجی‌گری می‌کند. ACEs هم درون‌نسلی و هم بین‌نسلی با pre-PSLEs مرتبط است و نشان‌دهنده مسیر انتقال استرس از اوایل زندگی به بزرگسالی است. این یافته‌ها اهمیت شناسایی و مداخله زودهنگام برای ACEs در مدیریت سلامت پیش از بارداری را برجسته می‌کند. تجارب دشوار دوران کودکی، مانند سوءاستفاده یا غفلت، می‌تواند بر سلامت و بهزیستی در سراسر زندگی تأثیر بگذارد. ما بررسی کردیم که آیا این تجارب، که به عنوان تجارب نامطلوب دوران کودکی (ACEs) شناخته می‌شوند، با رویدادهای پراسترس زندگی (SLEs) پیش از بارداری مرتبط هستند و آیا ناملایمات دوران کودکی مادر با استرس دخترش پیش از بارداری ارتباط دارد یا خیر. ما ۲٬۲۳۵ جفت مادر-دختر را در چین مورد مطالعه قرار دادیم. مادران و دختران تجارب دوران کودکی خود را گزارش کردند و دختران همچنین SLEs را در سال پیش از بارداری گزارش دادند. دریافتیم که هم ACEs مادر و هم فرزند با استرس بیشتر پیش از بارداری مرتبط است. بیشتر ارتباط بین ACEs مادر و استرس پیش از بارداری دختر توسط ACEs خود دختر توضیح داده می‌شود. این یافته‌ها اهمیت شناسایی و حمایت از زنانی با ناملایمات دوران کودکی پیش از بارداری را برای بهبود سلامت مادر و کودک برجسته می‌کند.

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موضوع‌ها و کلیدواژه‌ها

بهزیستیشناختمدیریتAdverse Childhood ExperiencesPregnancyintergenerational transmissionmaternal stress

ارجاع

Yang, H., Zhang, Z., Ding, W., Wang, H., Zhang, Y., Cheng, Y., Dai, J., Liu, Y., Wang, S., Zhou, Y., Cai, H., Zhao, Y., Liu, X., Zhang, S., Guo, Z., Zhu, X., & Wu, C. (2026). Adverse childhood experiences are linked to pre-pregnancy stressful life events across generations. Communications Medicine. https://doi.org/10.1038/s43856-026-01931-w

(Yang et al., 2026)

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قوانین پرسش و گفتگو
  1. با احترام و بدون توهین، تحقیر، برچسب‌زنی یا حمله‌ی شخصی با دیگران گفتگو کنید.
  2. از نوشتن هرگونه اطلاعات هویتی یا قابل‌شناسایی مراجعان، بیماران یا اشخاص ثالث، از جمله نام، شماره‌ی تماس، تصویر، نشانی، محل کار یا جزئیات منحصربه‌فرد پرونده خودداری کنید.
  3. اگر درباره‌ی یک تجربه‌ی بالینی سؤال می‌کنید، اطلاعات را تا حد ممکن بی‌نام و کلی بیان کنید تا امکان شناسایی فرد وجود نداشته باشد.
  4. این بخش برای یادگیری و گفت‌وگوی علمی است و جایگزین ارزیابی، تشخیص، مشاوره یا روان‌درمانی شخصی نیست.
  5. در شرایط بحران یا خطر آسیب به خود یا دیگران، به این بخش اتکا نکنید و برای دریافت کمک فوری با اورژانس اجتماعی ۱۲۳ یا صدای مشاور بهزیستی ۱۴۸۰ تماس بگیرید.
  6. انتشار تبلیغات، معرفی خدمات شخصی، شماره‌ی تلفن، شناسه‌ی شبکه‌های اجتماعی، پیوند تبلیغاتی یا درخواست جذب مراجع در این بخش مجاز نیست.
  7. در بیان ادعاهای علمی، به‌ویژه درباره‌ی اثربخشی درمان‌ها، تشخیص یا یافته‌های پژوهشی، تا حد امکان نام منبع معتبر، مقاله یا راهنمای علمی را ذکر کنید.
  8. از ارائه‌ی تشخیص قطعی، تجویز درمان یا دارو و توصیه‌های بالینی شخصی به سایر کاربران خودداری کنید.
  9. پاسخ‌هایی که کارشناسان فکر بنیان می‌دهند با برچسب «پاسخ فکر بنیان» یا «کارشناس فکر بنیان» نمایش داده می‌شوند و سایر نوشته‌ها بیانگر نظر کاربران هستند.
  10. گزارش نوشته‌ی نامناسب: اگر نوشته‌ای حاوی نقض محرمانگی، محتوای آسیب‌زا، توهین، تبلیغ یا تخلف از این قوانین است، گزینه‌ی «گزارش» را انتخاب کنید تا تیم سایت بررسی کند.

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چکیده

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