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Melanin-concentrating hormone inhibits PVN oxytocin neurons through barium-sensitive inwardly rectifying potassium channels and MCH-neuron ablation alters pup-directed aggression

هورمون متمرکزکننده ملانین نورون‌های اکسی‌توسین هسته پاراوانتریکولار را از طریق کانال‌های پتاسیمی ورودی‌ساز حساس به باریم مهار می‌کند و حذف نورون‌های MCH پرخاشگری نسبت به توله‌ها را تغییر می‌دهد

Tingbi Xiong, Fumihito Saitow, Ayumu Inutsuka, Tatsushi Onaka, Kazuo Yamada, Chitose Orikasa

Scientific Reports 2026
https://doi.org/10.1038/s41598-026-75712-9

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چکیده

Interactions between melanin-concentrating hormone (MCH) neurons and oxytocin neurons are crucial for parental care. Whole-cell patch-clamp recordings demonstrated that MCH inhibits paraventricular hypothalamic nucleus (PVN)-oxytocin neurons through activation of barium-sensitive inwardly rectifying potassium channels, potentially G-protein coupled inwardly rectifying potassium channels, and pup-directed aggression was positively related to loss of MCH neurons. Our findings offer a glimpse into the neural mechanisms underlying the evolutionary regulation of offspring caregiving and abuse in males.

چکیده به فارسی

برهم‌کنش‌های میان نورون‌های هورمون متمرکزکننده ملانین (MCH) و نورون‌های اکسی‌توسین برای مراقبت والدینی حیاتی هستند. ثبت‌های وصله‌ای کل‌سلولی نشان داد که MCH نورون‌های اکسی‌توسین هسته هیپوتالاموسی پاراوانتریکولار (PVN) را از طریق فعال‌سازی کانال‌های پتاسیمی ورودی‌ساز حساس به باریم، که احتمالاً از نوع کانال‌های پتاسیمی ورودی‌ساز جفت‌شونده با پروتئین G هستند، مهار می‌کند و پرخاشگری نسبت به توله‌ها با کاهش نورون‌های MCH رابطه مثبت دارد. یافته‌های ما نگاهی به سازوکارهای عصبی زیربنایی تنظیم تکاملی مراقبت و سوءرفتار نسبت به فرزندان در نرها ارائه می‌دهد.

ترجمه‌ی خودکار برای آشنایی سریع؛ برای نقل و ارجاع، متن اصلی ملاک است.

موضوع‌ها و کلیدواژه‌ها

روابط والد فرزندروانشناسی اجتماعیروان‌شناسی خانوادهmelanin-concentrating hormoneneuropeptide signalingoxytocin neuronsparaventricular nucleussocial behavior

ارجاع

Xiong, T., Saitow, F., Inutsuka, A., Onaka, T., Yamada, K., & Orikasa, C. (2026). Melanin-concentrating hormone inhibits PVN oxytocin neurons through barium-sensitive inwardly rectifying potassium channels and MCH-neuron ablation alters pup-directed aggression. Scientific Reports. https://doi.org/10.1038/s41598-026-75712-9

(Xiong et al., 2026)

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  1. با احترام و بدون توهین، تحقیر، برچسب‌زنی یا حمله‌ی شخصی با دیگران گفتگو کنید.
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  3. اگر درباره‌ی یک تجربه‌ی بالینی سؤال می‌کنید، اطلاعات را تا حد ممکن بی‌نام و کلی بیان کنید تا امکان شناسایی فرد وجود نداشته باشد.
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  6. انتشار تبلیغات، معرفی خدمات شخصی، شماره‌ی تلفن، شناسه‌ی شبکه‌های اجتماعی، پیوند تبلیغاتی یا درخواست جذب مراجع در این بخش مجاز نیست.
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