Melanin-concentrating hormone inhibits PVN oxytocin neurons through barium-sensitive inwardly rectifying potassium channels and MCH-neuron ablation alters pup-directed aggression
هورمون متمرکزکننده ملانین نورونهای اکسیتوسین هسته پاراوانتریکولار را از طریق کانالهای پتاسیمی ورودیساز حساس به باریم مهار میکند و حذف نورونهای MCH پرخاشگری نسبت به تولهها را تغییر میدهد
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چکیده
Interactions between melanin-concentrating hormone (MCH) neurons and oxytocin neurons are crucial for parental care. Whole-cell patch-clamp recordings demonstrated that MCH inhibits paraventricular hypothalamic nucleus (PVN)-oxytocin neurons through activation of barium-sensitive inwardly rectifying potassium channels, potentially G-protein coupled inwardly rectifying potassium channels, and pup-directed aggression was positively related to loss of MCH neurons. Our findings offer a glimpse into the neural mechanisms underlying the evolutionary regulation of offspring caregiving and abuse in males.
چکیده به فارسی
برهمکنشهای میان نورونهای هورمون متمرکزکننده ملانین (MCH) و نورونهای اکسیتوسین برای مراقبت والدینی حیاتی هستند. ثبتهای وصلهای کلسلولی نشان داد که MCH نورونهای اکسیتوسین هسته هیپوتالاموسی پاراوانتریکولار (PVN) را از طریق فعالسازی کانالهای پتاسیمی ورودیساز حساس به باریم، که احتمالاً از نوع کانالهای پتاسیمی ورودیساز جفتشونده با پروتئین G هستند، مهار میکند و پرخاشگری نسبت به تولهها با کاهش نورونهای MCH رابطه مثبت دارد. یافتههای ما نگاهی به سازوکارهای عصبی زیربنایی تنظیم تکاملی مراقبت و سوءرفتار نسبت به فرزندان در نرها ارائه میدهد.
ترجمهی خودکار برای آشنایی سریع؛ برای نقل و ارجاع، متن اصلی ملاک است.
با احترام و بدون توهین، تحقیر، برچسبزنی یا حملهی شخصی با دیگران گفتگو کنید.
از نوشتن هرگونه اطلاعات هویتی یا قابلشناسایی مراجعان، بیماران یا اشخاص ثالث، از جمله نام، شمارهی تماس، تصویر، نشانی، محل کار یا جزئیات منحصربهفرد پرونده خودداری کنید.
اگر دربارهی یک تجربهی بالینی سؤال میکنید، اطلاعات را تا حد ممکن بینام و کلی بیان کنید تا امکان شناسایی فرد وجود نداشته باشد.
این بخش برای یادگیری و گفتوگوی علمی است و جایگزین ارزیابی، تشخیص، مشاوره یا رواندرمانی شخصی نیست.
در شرایط بحران یا خطر آسیب به خود یا دیگران، به این بخش اتکا نکنید و برای دریافت کمک فوری با اورژانس اجتماعی ۱۲۳ یا صدای مشاور بهزیستی ۱۴۸۰ تماس بگیرید.
انتشار تبلیغات، معرفی خدمات شخصی، شمارهی تلفن، شناسهی شبکههای اجتماعی، پیوند تبلیغاتی یا درخواست جذب مراجع در این بخش مجاز نیست.
در بیان ادعاهای علمی، بهویژه دربارهی اثربخشی درمانها، تشخیص یا یافتههای پژوهشی، تا حد امکان نام منبع معتبر، مقاله یا راهنمای علمی را ذکر کنید.
از ارائهی تشخیص قطعی، تجویز درمان یا دارو و توصیههای بالینی شخصی به سایر کاربران خودداری کنید.
پاسخهایی که کارشناسان فکر بنیان میدهند با برچسب «پاسخ فکر بنیان» یا «کارشناس فکر بنیان» نمایش داده میشوند و سایر نوشتهها بیانگر نظر کاربران هستند.
گزارش نوشتهی نامناسب: اگر نوشتهای حاوی نقض محرمانگی، محتوای آسیبزا، توهین، تبلیغ یا تخلف از این قوانین است، گزینهی «گزارش» را انتخاب کنید تا تیم سایت بررسی کند.
Over the last decade, there has been a visible surge of students participating in and leading different forms of activism. Following the cultural reckoning of 2020, the United States saw a rise in awareness and engagement in activism among young individuals. Continuing this trend, higher education institutions have seen an increase in on-campus demonstrations in recent years. Given the recent increase in activism, political engagement, and the globalization of social issues, this study examined how attitudes, beliefs, individual factors, and prior behaviors relate to undergraduate students’ willingness to engage in different forms of activism (i.e., conventional and high-risk). Across both forms of activism, institutional advocacy (i.e., the behavioral targeting of institutional racism) was the most consistent unique predictor of a student's willingness to engage in activism. Need for cognition and individual advocacy were significantly and positively related to conventional activism, whereas political orientation was negatively related to it. Social justice orientation was significantly and negatively related to high-risk activism.
Social capital represents a relational resource developed through trust, professional networks, collaboration, peer support, and knowledge exchange. In the context of Social Studies Education, social capital can support teachers in accessing information, experiences, and professional resources relevant to professional development and instructional planning. This study aims to analyze the conceptualization of teachers’ social capital, identify its dimensions in relation to teacher professionalism, and examine its relevance to Social Studies teaching practices and instructional planning. The study employs a Systematic Literature Review (SLR) approach guided by the PRISMA 2020 framework. The literature analyzed consists of scholarly publications published between 2023 and 2026 in Indonesian and English that met the established inclusion criteria. The data were analyzed through thematic synthesis based on conceptual dimensions, forms of professional relationships, and their contributions to teaching practices. The synthesis indicates that social capital facilitates teachers’ access to information, experiences, feedback, and professional support through networks and collaborative relationships. These resources can strengthen professional learning and pedagogical decision-making relevant to Social Studies instructional planning. However, empirical evidence directly linking teachers’ social capital to the quality of Social Studies instructional planning remains limited. These findings highlight the need for further research on how social capital can be translated into improvements in the quality of Social Studies instructional planning components.
Children's behaviour and social adjustment within the classroom are important considerations. Behaviour can refer to how a pupil engages with learning tasks, follows instructions, works with others and interacts within the classroom. Social adjustment can relate to how children feel they fit in, build friendships, communicate effectively and feel included. Although behaviour and social adjustment are two distinct areas, they will be influenced by each other. This conceptual article will discuss the relationship between behaviour and social adjustment for upper primary school students. Using theories such as ecological systems, social learning and sociocultural. School engagement, friendships and school belonging will also be discussed. It is important to consider how behaviour should be seen as more than just an individual trait. Family factors, teaching style, peer relationships, individual differences and school factors can influence how a pupil behaves. A strength based approach to children's behaviour and social adjustment will be advocated. The article will conclude with key implications for classroom settings and recommendations for future research. Future research should be culturally aware, developmentally appropriate and ethical. This article is theoretical and will not give any findings.
Toilet training is an essential developmental process that fosters discipline and independence in early childhood. The acquisition of toileting skills is significantly influenced by parenting approaches. Authoritative (democratic) parenting, characterized by warmth, two-way communication, and clear boundaries, offers supportive guidance during this developmental transition. This study aimed to investigate the effect of an authoritative parenting style on toilet training ability among children aged 3–4 years. A quantitative research design with a correlational approach was employed, involving 206 parents of children aged 3–4 years selected via questionnaire distribution. Data were collected using the adapted Parenting Styles and Dimensions Questionnaire-Short Version (PSDQ-SV) and the Toilet Training Readiness Scale (TTRS), and analyzed using binary logistic regression. The results revealed a statistically significant association between authoritative parenting and toilet training outcome (p = .018, p .05), though accounting for a modest proportion of the overall variance. These findings suggest that while authoritative parenting contributes positively to early toilet training progression, consistent parental guidance and child-centered readiness factors remain vital.
This mixed-methods study examined whether first-year teachers could improve relationships with students through Positive Behavioral Interventions and Supports (PBIS). Fifty novice teachers implemented one of three PBIS strategies: daily one-on-one conversation, verbal praise, or immediate rewards with 192 selected students over a two-week period. Teacher-student relationships were measured using the Student-Teacher Relationship Scale (STRS) before and after the intervention. Results showed significant reductions in conflict (t(191) = 7.14, p < .001, d = 0.98) and moderate increases in closeness (t(191) = –7.11, p < .001, d = 0.67). No significant differences emerged across grade levels, teacher and student gender, or PBIS strategy type. Thematic analysis of teacher reflections highlighted improvements in engagement, cooperation, emotional regulation, and relational trust. Although the study was limited by its two-week duration and reliance on teacher self-reports, the findings demonstrate that even brief PBIS interventions can yield measurable relational benefits. Implications are discussed for teacher preparation programs and school-based practice. Keywords: teacher-student relationships, Positive Behavioral Interventions and Supports (PBIS), teacher preparation programs, first-year/novice teachers, school climate.