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Vulnerability and resilience to activity-based anorexia are not sex-dependent

آسیب‌پذیری و تاب‌آوری در برابر بی‌اشتهایی مبتنی بر فعالیت وابسته به جنسیت نیست

Julie Zhao, Jeff A. Beeler, Nesha S. Burghardt

Frontiers in Psychiatry 2026 Vol. 17
https://doi.org/10.3389/fpsyt.2026.1897501

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چکیده

Introduction Anorexia nervosa (AN) is more prevalent in women than men, although rates in men are rising. Animal models can provide insight into whether this differential prevalence is rooted in biological mechanisms, but prior studies have yielded conflicting findings. Using the activity-based anorexia (ABA) model, we previously demonstrated that female mice exhibit distinct vulnerable and resilient phenotypes. Here, we use this phenotypic framework to investigate sex differences in ABA susceptibility. Methods We tested young adult male C57BL/6N mice using the same ABA protocol used to test age-matched C57BL/6N females. Individual differences in daily bodyweight, food intake, water intake, and wheel running were analyzed and compared across sexes. Results Males exhibit the same vulnerable and resilient phenotypes as females, with no sex difference in the proportion of mice exhibiting each phenotype or the repertoire of behaviors characterizing them. In both sexes, vulnerable mice exhibit catastrophic weight loss that is associated with excessive light cycle running, while resilient mice exhibit weight stabilization that is associated with adaptive changes in consumption. When food is available, vulnerable mice do not run more than resilient mice, indicating that vulnerability is not characterized by a decision to run instead of eat in either sex. Conclusions Our findings indicate that there are no sex differences in ABA in C57BL/6N mice. The shared behavioral responses to starvation observed across sexes demonstrate that ABA can be used to model adaptive and maladaptive responses to food restriction in men and women.

چکیده به فارسی

مقدمه: بی‌اشتهایی عصبی (AN) در زنان شایع‌تر از مردان است، هرچند نرخ آن در مردان رو به افزایش است. مدل‌های حیوانی می‌توانند بینشی درباره این‌که آیا این شیوع متفاوت ریشه در سازوکارهای زیستی دارد یا خیر، ارائه دهند، اما پژوهش‌های پیشین یافته‌های متناقضی داشته‌اند. با استفاده از مدل بی‌اشتهایی مبتنی بر فعالیت (ABA)، پیش‌تر نشان دادیم که موش‌های ماده فنوتیپ‌های آسیب‌پذیر و تاب‌آور متمایزی را نشان می‌دهند. در این پژوهش، از این چارچوب فنوتیپی برای بررسی تفاوت‌های جنسی در آسیب‌پذیری نسبت به ABA استفاده کردیم. روش‌ها: موش‌های نر بالغ جوان نژاد C57BL/6N با همان پروتکل ABA که برای موش‌های ماده هم‌سن C57BL/6N به کار رفته بود، آزمون شدند. تفاوت‌های فردی در وزن بدن روزانه، مصرف غذا، مصرف آب و دویدن چرخشی تحلیل و بین دو جنس مقایسه شد. یافته‌ها: موش‌های نر همان فنوتیپ‌های آسیب‌پذیر و تاب‌آور را مانند موش‌های ماده نشان دادند و تفاوت معناداری در نسبت موش‌هایی که هر فنوتیپ را نشان می‌دهند یا در الگوی رفتاری مشخص‌کننده آن‌ها بین دو جنس مشاهده نشد. در هر دو جنس، موش‌های آسیب‌پذیر کاهش وزن فاجعه‌آمیزی را تجربه کردند که با دویدن بیش از حد در چرخه نوری همراه بود، در حالی که موش‌های تاب‌آور تثبیت وزن را نشان دادند که با تغییرات سازگارانه در مصرف همراه بود. زمانی که غذا در دسترس است، موش‌های آسیب‌پذیر بیش از موش‌های تاب‌آور نمی‌دوند، که نشان می‌دهد آسیب‌پذیری در هیچ‌یک از دو جنس با تصمیم به دویدن به جای خوردن مشخص نمی‌شود. نتیجه‌گیری: یافته‌های ما نشان می‌دهد که در موش‌های C57BL/6N تفاوت جنسی در ABA وجود ندارد. پاسخ‌های رفتاری مشترک به گرسنگی که در هر دو جنس مشاهده شد، نشان می‌دهد که ABA می‌تواند برای مدل‌سازی پاسخ‌های سازگارانه و ناسازگارانه به محدودیت غذایی در مردان و زنان به کار رود.

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موضوع‌ها و کلیدواژه‌ها

تفاوت‌های جنسیتیAnorexia nervosaC57BL/6N miceactivity-based anorexiadietary restrictionsex differencesstarvationvulnerability and resiliencewheel running

ارجاع

Zhao, J., Beeler, J. A., & Burghardt, N. S. (2026). Vulnerability and resilience to activity-based anorexia are not sex-dependent. Frontiers in Psychiatry, 17. https://doi.org/10.3389/fpsyt.2026.1897501

(Zhao et al., 2026)

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PSYCHOLOGICAL WELL-BEING IN INDUSTRY 4.0: A CONCEPTUAL STUDY OF GENDER DIFFERENCES

Nur Dalilah Dahlan; Mohamad Firdaus Ahmad; AHMAD FIKRI MOHD KASSIM Quantum Journal of Social Sciences and Humanities, 2026, Vol. 7, Issue 5, pp. 376-386 https://doi.org/10.55197/qjssh.v7i5.1241

چکیده

The rapid digitalisation and technological advancements associated with Industry 4.0 are transforming work environments, job demands, and employee expectations across sectors. While these changes create new opportunities for flexibility, innovation, and productivity, they also introduce increased pressures that can affect workers’ psychological well-being in different ways. Emerging literature highlights mental health and well-being as critical concerns in the digital era, yet limited attention has been given to how these changes are experienced differently by men and women. This conceptual paper aims to examine gender differences in psychological well-being within the context of Industry 4.0, with a focus on work demands, work–life balance, and organisational support. Through a critical review of existing empirical and theoretical studies, a conceptual framework is proposed, drawing on the Job Demands–Resources (JD–R) theory and supported by Ryff’s Psychological Well-Being model. This framework provides an understanding of how demands and resources associated with Industry 4.0 shape the well-being of men and women in both similar and different ways. The study offers insights for policymakers, organisations, and researchers in developing more inclusive and gender-sensitive strategies to support employee well-being in technology-driven workplaces and contributes to discussions on sustainable work and mental health in the Fourth Industrial Revolution.

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A COMPARATIVE STUDY OF WRITING SKILLS IN INTELLECTUALLY DISABLED BOYS VERSUS GIRLS AT THE SECONDARY LEVEL RAIPUR, CHHATTISGARH

Sadhana Nayak Journal of Integrative Science and Societal Impact, 2026, Vol. 2, Issue 3, pp. 16-19 https://doi.org/10.29121/jissi.v2.i3.2026.109

چکیده

This research study was conducted to provide a comparative analysis of the writing skills of intellectually disabled boys and girls studying at the secondary level. The primary objective of the study was to test the hypothesis that "intellectually disabled boys at the secondary level will exhibit higher writing skills compared to intellectually disabled girls." A total of 60 intellectually disabled students (30 boys and 30 girls, aged 12–18 years) were selected from special and inclusive schools in the Raipur district (Chhattisgarh) using purposive random sampling. Data were collected using a standardized 'Writing Skill Assessment Scale' (WSAS), which evaluated fine motor skills, shape imitation, clarity of letters/words, and copying speed. Statistical analysis of the data was performed using the mean, standard deviation (SD), and t-test. The results indicated no statistically significant difference between the scores of boys (M=54.20, SD=8.15) and girls (M=52.80, SD=8.40) (t=0.65, p=.518). Consequently, the formulated hypothesis is rejected. The study concludes that, in the context of intellectual disability, the development of writing skills is not gender-dependent but rather relies on individual motor coordination and regular practice.

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Decomposing the gender gap in subjective well-being: evidence from a machine learning-based switching framework

Jie Mi; Chao Li; Alexander Ryota Keeley; Jiaxu Zhang; Shunsuke Managi Humanities and Social Sciences Communications, 2026 https://doi.org/10.1057/s41599-026-09543-4

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Human well-being has received increasing attention as an indicator of individual and social health and as a consideration in public policy. Gender differences in subjective well-being (SWB), a widely accepted indicator of human well-being, have long been documented. However, explanations of these gender differences remain varied and inconclusive. This study utilizes Gallup World Poll data comprising 1,911,212 observations from 2009 to 2022. Employing advanced machine-learning techniques within an Exogenous Switching Treatment Effect Model (ESTEM) framework, we decompose the gender gap in SWB into differences in characteristics and differences in regime-specific returns. Conditional on observed characteristics and under a common predictive regime, the model predicts higher SWB for men. In contrast, the regime-specific returns component is associated with lower predicted well-being under the male regime. This component also increases over time, widening the estimated gender gap in SWB, while its magnitude varies across countries. The results suggest the potential relevance of institutional flexibility and reduced gender-role pressures for addressing gender disparities in human well-being.

سایت ناشر ↗ دسترسی آزاد

Decomposition of gender disparities in abnormal sleep duration among Chinese older adults: evidence from a national survey

Na Zhang; Mengqian Wu; Kaijun Han; Manlan He; Lu Chen Frontiers in Public Health, 2026, Vol. 14, pp. 1903876 https://doi.org/10.3389/fpubh.2026.1903876

چکیده

Background Sleep duration is an important component of healthy aging, yet gender differences in short and long sleep among older adults remain insufficiently understood. This study aimed to examine gender differences in sleep duration among Chinese older adults and quantify the contributions of socioeconomic, behavioral, functional, and health-related factors to these differences. Methods Data were obtained from 9,590 adults aged ≥65 years who participated in the 2018 wave of the Chinese Longitudinal Healthy Longevity Survey. Sleep duration was self-reported and categorized as short (<6 h), normal (6–8 h), or long (>8 h). Multinomial logistic regression was used to identify factors associated with short and long sleep, with weighted analyses and Poisson regression performed as sensitivity analyses. Separate Fairlie decomposition analyses were conducted for short and long sleep to quantify the contributions of observed characteristics to gender differences. Results Overall, 44.95% of participants had abnormal sleep duration, with a higher prevalence among women than men (46.87% vs. 42.66%, p < 0.001). Compared with men, women had a higher relative risk of short sleep (RRR = 1.399, 95% CI: 1.204–1.625) but a lower relative risk of long sleep (RRR = 0.856, 95% CI: 0.754–0.972). The association with short sleep remained significant in the weighted analysis (RRR = 1.530, 95% CI: 1.210–1.935), whereas the gender difference in long sleep was attenuated (RRR = 0.821, 95% CI: 0.661–1.021). For short sleep, observed characteristics explained 21.65% of the gender disparity. Education (22.75%), depressive symptoms (11.07%), IADL limitation (6.02%), and self-assessed health (4.82%) contributed positively to the disparity, whereas smoking status (−22.57%), drinking status (−12.45%), and exercise (−4.87%) partially offset it. The gender difference in long sleep was negligible, with substantial offsetting contributions across factors. Conclusion Gender differences in sleep duration among Chinese older adults were primarily concentrated in short sleep, with women experiencing a higher risk. Socioeconomic, behavioral, psychological, and functional characteristics contributed to this disparity, although most of the short-sleep difference remained unexplained. Gender-sensitive interventions addressing educational disadvantage, depressive symptoms, functional limitations, and health behaviors may help reduce inequalities in sleep duration among older adults.

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