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Hematological alterations in adolescent girls with restrictive anorexia nervosa and secondary amenorrhea at the time of diagnosis

تغییرات هماتولوژیک در دختران نوجوان مبتلا به بی‌اشتهایی عصبی محدودکننده و آمنوره ثانویه در زمان تشخیص

Katarina Sebekova, Alexandra Gaál Kovalč, Ľubica Tichá, Ľudmila Podracká

Korean Journal of Pediatrics 2026 Vol. 68(6)
https://doi.org/10.3345/cep.2026.00808

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چکیده

Background: Anorexia nervosa (AN) is associated with chronic energy deficiency and endocrine adaptations affecting multiple organ systems involving bone meta bolism and hematological homeostasis.However, early alterations in peripheral blood counts of adolescents with a clinically homogeneous AN phenotype remain in sufficiently characterized.Purpose: To examine the differences in blood counts and associated bone and endocrine parameters between adolescent girls with newly diagnosed restrictive AN and secondary amenorrhea and healthy agematched controls. Methods:The study included 59 patients and 20 controls.Hematological indices, anthropometric characteristics, body composition, bone mineral status, bone turnover, and endocrine status markers were compared, and a multivariate analysis was used to identify the predictors of blood counts.Results: Compared to controls, patients had significantly lower leukocyte, erythrocyte, and platelet counts (all P< 0.01), and 29% had cytopenia in at least one parameter.Bone formation markers (osteocalcin, aminoterminal propeptide of human procollagen type I, and alkaline phosphatase) and key endocrine parameters (insulin like growth factor1, estradiol, and free thyroxine) were suppressed.These alterations were also observed in pati ents with a normal bone mineral density and adequate vitamin B12 and folate levels.A multivariate analysis iden tified endocrine and bonerelated predictors of blood counts in controls but no consistent pattern of predictors in patients.Conclusion: Adolescent girls with restrictive AN and secondary amenorrhea demonstrated hematological al tera tions at the time of diagnosis despite the absence of a measurable skeletal impairment or micronutrient defici ency.These findings suggest that a chronic energy defici ency and endocrine adaptation are associated with early disturbances in hematological homeostasis.Peripheral blood count may represent an accessible clinical marker of systemic disturbances.

چکیده به فارسی

زمینه: بی‌اشتهایی عصبی (AN) با کمبود مزمن انرژی و سازگاری‌های غدد درون‌ریز همراه است که بر چندین دستگاه بدن از جمله متابولیسم استخوان و هموستاز هماتولوژیک تأثیر می‌گذارد. با این حال، تغییرات اولیه در شمارش سلول‌های خونی محیطی نوجوانان با فنوتیپ بالینی همگن AN به اندازه کافی توصیف نشده است. هدف: بررسی تفاوت‌های شمارش سلول‌های خونی و پارامترهای مرتبط با استخوان و غدد درون‌ریز بین دختران نوجوان با تشخیص جدید بی‌اشتهایی عصبی محدودکننده و آمنوره ثانویه و افراد سالم هم‌سن. روش‌ها: این مطالعه شامل ۵۹ بیمار و ۲۰ فرد کنترل بود. شاخص‌های هماتولوژیک، ویژگی‌های آنتروپومتریک، ترکیب بدن، وضعیت مواد معدنی استخوان، گردش استخوان و نشانگرهای وضعیت غدد درون‌ریز مقایسه شد و از تحلیل چندمتغیره برای شناسایی پیش‌بینی‌کننده‌های شمارش سلول‌های خونی استفاده گردید. نتایج: در مقایسه با گروه کنترل، بیماران به طور معناداری شمارش لکوسیت، اریتروسیت و پلاکت پایین‌تری داشتند (همه P<0.01) و ۲۹٪ در حداقل یکی از پارامترها سیتوپنی داشتند. نشانگرهای تشکیل استخوان (استئوکلسین، آمینوترمینال پروپپتید پروکلاژن نوع I انسانی و آلکالین فسفاتاز) و پارامترهای کلیدی غدد درون‌ریز (فاکتور رشد شبه انسولین ۱، استرادیول و تیروکسین آزاد) سرکوب شده بودند. این تغییرات همچنین در بیمارانی با تراکم مواد معدنی استخوان طبیعی و سطوح کافی ویتامین B12 و فولات مشاهده شد. تحلیل چندمتغیره، پیش‌بینی‌کننده‌های مرتبط با غدد درون‌ریز و استخوان را در گروه کنترل شناسایی کرد اما الگوی ثابتی از پیش‌بینی‌کننده‌ها در بیماران مشاهده نشد. نتیجه‌گیری: دختران نوجوان مبتلا به AN محدودکننده و آمنوره ثانویه در زمان تشخیص، تغییرات هماتولوژیک را علی‌رغم عدم وجود اختلال قابل اندازه‌گیری اسکلتی یا کمبود ریزمغذی‌ها نشان دادند. این یافته‌ها نشان می‌دهد که کمبود مزمن انرژی و سازگاری غدد درون‌ریز با اختلالات زودهنگام در هموستاز هماتولوژیک مرتبط است. شمارش سلول‌های خونی محیطی می‌تواند به عنوان یک نشانگر بالینی قابل دسترس برای اختلالات سیستمیک مطرح شود.

ترجمه‌ی خودکار برای آشنایی سریع؛ برای نقل و ارجاع، متن اصلی ملاک است.

موضوع‌ها و کلیدواژه‌ها

آموزش سلامتاختلال پرخوریسلامت روانیAnorexia nervosabone mineral densitybone turnover markerscytopeniahematological changesosteocalcinsecondary amenorrheaنوجوانان

ارجاع

Sebekova, K., Kovalč, A. G., Tichá, Ľ., & Podracká, Ľ. (2026). Hematological alterations in adolescent girls with restrictive anorexia nervosa and secondary amenorrhea at the time of diagnosis. Korean Journal of Pediatrics, 68(6). https://doi.org/10.3345/cep.2026.00808

(Sebekova et al., 2026)

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قوانین پرسش و گفتگو
  1. با احترام و بدون توهین، تحقیر، برچسب‌زنی یا حمله‌ی شخصی با دیگران گفتگو کنید.
  2. از نوشتن هرگونه اطلاعات هویتی یا قابل‌شناسایی مراجعان، بیماران یا اشخاص ثالث، از جمله نام، شماره‌ی تماس، تصویر، نشانی، محل کار یا جزئیات منحصربه‌فرد پرونده خودداری کنید.
  3. اگر درباره‌ی یک تجربه‌ی بالینی سؤال می‌کنید، اطلاعات را تا حد ممکن بی‌نام و کلی بیان کنید تا امکان شناسایی فرد وجود نداشته باشد.
  4. این بخش برای یادگیری و گفت‌وگوی علمی است و جایگزین ارزیابی، تشخیص، مشاوره یا روان‌درمانی شخصی نیست.
  5. در شرایط بحران یا خطر آسیب به خود یا دیگران، به این بخش اتکا نکنید و برای دریافت کمک فوری با اورژانس اجتماعی ۱۲۳ یا صدای مشاور بهزیستی ۱۴۸۰ تماس بگیرید.
  6. انتشار تبلیغات، معرفی خدمات شخصی، شماره‌ی تلفن، شناسه‌ی شبکه‌های اجتماعی، پیوند تبلیغاتی یا درخواست جذب مراجع در این بخش مجاز نیست.
  7. در بیان ادعاهای علمی، به‌ویژه درباره‌ی اثربخشی درمان‌ها، تشخیص یا یافته‌های پژوهشی، تا حد امکان نام منبع معتبر، مقاله یا راهنمای علمی را ذکر کنید.
  8. از ارائه‌ی تشخیص قطعی، تجویز درمان یا دارو و توصیه‌های بالینی شخصی به سایر کاربران خودداری کنید.
  9. پاسخ‌هایی که کارشناسان فکر بنیان می‌دهند با برچسب «پاسخ فکر بنیان» یا «کارشناس فکر بنیان» نمایش داده می‌شوند و سایر نوشته‌ها بیانگر نظر کاربران هستند.
  10. گزارش نوشته‌ی نامناسب: اگر نوشته‌ای حاوی نقض محرمانگی، محتوای آسیب‌زا، توهین، تبلیغ یا تخلف از این قوانین است، گزینه‌ی «گزارش» را انتخاب کنید تا تیم سایت بررسی کند.

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چکیده

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