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چکیده
Obsessive-compulsive disorder (OCD) is a highly debilitating and often chronic condition. A large percentage of patients do not respond to first-line treatments with selective serotonin reuptake inhibitors (SSRIs) or cognitive behavioral therapy (CBT), underscoring the need for novel therapeutic approaches. In this context, promising innovative treatments have recently emerged for OCD; these include pharmacological options such as ketamine and psilocybin—which may exert rapid-acting effects—as well as neuromodulatory treatments such as repetitive transcranial magnetic stimulation (rTMS) and deep brain stimulation (DBS). In addition, growing evidence links early life stress with neuroinflammatory pathways and dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis in OCD, opening novel treatment targets. While preliminary clinical trials of novel rapid-acting substances in OCD are encouraging, results are mixed and evidence of repeated dosing is scarce. This narrative review synthesizes current evidence on rapid-acting and neuromodulatory treatments for OCD, with a particular focus on stress-related mechanisms, offering new therapeutic possibilities as well as avenues for future research.
چکیده به فارسی
اختلال وسواس فکری-عملی یک وضعیت بسیار ناتوانکننده و اغلب مزمن است. درصد بالایی از بیماران به درمانهای خط اول با مهارکنندههای بازجذب سروتونین انتخابی (SSRIs) یا درمان شناختی-رفتاری (CBT) پاسخ نمیدهند که این امر بر نیاز به رویکردهای درمانی نوین تأکید دارد. در این زمینه، درمانهای نوآورانه و امیدبخشی اخیراً برای اختلال وسواس فکری-عملی مطرح شدهاند؛ این درمانها شامل گزینههای دارویی مانند کتامین و سیلوسایبین—که ممکن است اثرات سریعالظهور داشته باشند—و همچنین درمانهای نوروماژولاتوری مانند تحریک مغناطیسی ترانسکرانیال تکرارشونده (rTMS) و تحریک عمقی مغز (DBS) هستند. علاوه بر این، شواهد فزایندهای ارتباط استرس اوایل زندگی با مسیرهای نوروانفلاماتوری و اختلال در محور هیپوتالاموس-هیپوفیز-آدرنال (HPA) را در اختلال وسواس فکری-عملی نشان میدهد که اهداف درمانی جدیدی را مطرح میکند. اگرچه کارآزماییهای بالینی مقدماتی مواد سریعالاثر نوین در اختلال وسواس فکری-عملی امیدبخش هستند، اما نتایج متناقض بوده و شواهد اندکی در مورد دوزهای مکرر وجود دارد. این مرور روایتی، شواهد فعلی درباره درمانهای سریعالاثر و نوروماژولاتوری برای اختلال وسواس فکری-عملی را با تمرکز ویژه بر سازوکارهای مرتبط با استرس مرور میکند و امکانات درمانی جدید و مسیرهایی برای پژوهشهای آینده ارائه میدهد.
ترجمهی خودکار برای آشنایی سریع؛ برای نقل و ارجاع، متن اصلی ملاک است.
Saelens, J., Stadler, F., Forschauer, V., Baldermann, J. C., Henter, I. D., Zarate, C. A., & Kraus, C. (2026). Rapid-acting and neuromodulatory interventions for treatment-resistant OCD: clinical implications in stress reduction. Translational Psychiatry. https://doi.org/10.1038/s41398-026-04480-x
با احترام و بدون توهین، تحقیر، برچسبزنی یا حملهی شخصی با دیگران گفتگو کنید.
از نوشتن هرگونه اطلاعات هویتی یا قابلشناسایی مراجعان، بیماران یا اشخاص ثالث، از جمله نام، شمارهی تماس، تصویر، نشانی، محل کار یا جزئیات منحصربهفرد پرونده خودداری کنید.
اگر دربارهی یک تجربهی بالینی سؤال میکنید، اطلاعات را تا حد ممکن بینام و کلی بیان کنید تا امکان شناسایی فرد وجود نداشته باشد.
این بخش برای یادگیری و گفتوگوی علمی است و جایگزین ارزیابی، تشخیص، مشاوره یا رواندرمانی شخصی نیست.
در شرایط بحران یا خطر آسیب به خود یا دیگران، به این بخش اتکا نکنید و برای دریافت کمک فوری با اورژانس اجتماعی ۱۲۳ یا صدای مشاور بهزیستی ۱۴۸۰ تماس بگیرید.
انتشار تبلیغات، معرفی خدمات شخصی، شمارهی تلفن، شناسهی شبکههای اجتماعی، پیوند تبلیغاتی یا درخواست جذب مراجع در این بخش مجاز نیست.
در بیان ادعاهای علمی، بهویژه دربارهی اثربخشی درمانها، تشخیص یا یافتههای پژوهشی، تا حد امکان نام منبع معتبر، مقاله یا راهنمای علمی را ذکر کنید.
از ارائهی تشخیص قطعی، تجویز درمان یا دارو و توصیههای بالینی شخصی به سایر کاربران خودداری کنید.
پاسخهایی که کارشناسان فکر بنیان میدهند با برچسب «پاسخ فکر بنیان» یا «کارشناس فکر بنیان» نمایش داده میشوند و سایر نوشتهها بیانگر نظر کاربران هستند.
گزارش نوشتهی نامناسب: اگر نوشتهای حاوی نقض محرمانگی، محتوای آسیبزا، توهین، تبلیغ یا تخلف از این قوانین است، گزینهی «گزارش» را انتخاب کنید تا تیم سایت بررسی کند.
Background: Awareness of youth-friendly sexual and reproductive health services (YFSRHS) is an important starting point for enabling young people to identify and seek appropriate sexual and reproductive health information and care. However, awareness of these services may vary across settings, including higher education institutions. Objective: To determine the level of awareness of YFSRHS among undergraduate students at Saint Augustine University of Tanzania (SAUT), Malimbe Campus. Methods: A quantitative descriptive cross-sectional study was conducted among undergraduate students at SAUT Malimbe Campus. Data were collected using a structured, self-administered questionnaire. Of 109 questionnaires distributed, 108 completed questionnaires were included in the analysis. Descriptive statistics were used to summarize students’ awareness and reported sources of information. Results: Of the 108 respondents, 96 (88.9%) reported having heard of YFSRHS, while 12 (11.1%) had not. Social media was the most frequently reported source of information (44.0%), followed by friends or peers (41.0%) and health facilities (36.0%). University programmes and posters or advertisements were reported less frequently. Conclusion: Most respondents had heard of YFSRHS, with social media and peer networks serving as prominent information channels. Strengthening accurate information through these channels, alongside university-based communication, may help address the awareness gap among students who remain unreached.
Religious education is often expected to promote tolerance, but respect for religious difference does not necessarily ensure accurate understanding of religious others. This study examines how religious education policies in Indonesia and England emphasize different forms of cognitive tolerance. Using qualitative document analysis and comparative policy analysis, the study analyzes selected legal, curricular, and pedagogical documents through four components: Knowledge of Religious Others, Recognition of Internal Diversity, Critical Reflection, and Understanding Commonalities and Differences. Indonesian policy gives greater relative emphasis to understanding commonalities and differences within religion-specific formation, social harmony, and responsible citizenship. English policy gives greater emphasis to critical reflection and knowledge of religious and non-religious worldviews through shared enquiry. Recognition of Internal Diversity appears in similar proportions in both datasets, but it serves different curricular functions. The findings show differently configured pathways toward cognitive tolerance, combining the same cognitive components with different relative emphases and curricular purposes.
Although physical activity enjoyment is associated with athletes’ psychological outcomes, the mechanisms underlying its relationship with mental well-being remain unclear. This study examined the mediating role of loneliness among athletes. A correlational survey design was employed. The participants consisted of 350 athletes selected through criterion sampling, including 178 females (Mage= 20.58 ± 1.99) and 172 males (Mage= 21.91 ± 4.88). Data were collected using the Physical Activity Enjoyment Scale, UCLA Loneliness Scale–Short Form, and Warwick-Edinburgh Mental Well-Being Scale. Pearson correlation analysis and PROCESS Macro Model 4 mediation analysis were conducted, and indirect effects were tested using 5,000 bootstrap samples. Physical activity enjoyment was positively associated with mental well-being (r= .586, p< .01) and negatively associated with loneliness (a= −.196, p< .01). Loneliness was negatively associated with mental well-being (b= −.447, p< .01). The mediation analysis revealed a significant indirect effect of physical activity enjoyment on mental well-being through loneliness (indirect effect= .088, 95% CI [.026, .147]). These findings indicate that enjoyment of physical activity contributes to athletes’ mental well-being and that loneliness partially explains this relationship. The results emphasize the importance of considering social connectedness and psychological experiences in understanding athletes’ well-being.
Experiences of bullying can have significant psychological consequences, including an increased risk of social anxiety. This study aimed to examine changes in social anxiety following Virtual Reality Social Exposure (VRSE) among bullying victims. A one-group pretest–posttest design without a control group was employed with 12 participants. The intervention consisted of three gradual exposure sessions in virtual environments representing social situations. Social anxiety was measured before and after the intervention, and the data were analyzed using the Wilcoxon Signed-Rank Test. The results indicated a statistically significant decrease in social anxiety scores following the intervention (p = 0.002), with a reported effect size of 0.974. These findings suggest that VRSE may be a promising approach for reducing social anxiety among bullying victims. However, the absence of a control group and the small sample size limit conclusions regarding its effectiveness and safety. Further studies with larger samples, control groups, and systematic safety assessments are needed.
Stress arising from academic, professional and financial demands is common among students and young professionals, and the coping methods within easiest reach, such as listening to music, do not always suffice. This paper presents a survey-driven design for a virtual reality (VR) gadget that combines selectable immersive natural environments, environment-matched sound therapy and heart-rate biofeedback for short relaxation sessions. An online questionnaire completed by 24 respondents, mostly college students, supplies the user requirements. Among those who answer the relevant items, 65.2% report daily stress, 73.9% name academic or job pressure as the main cause, and 47.8% state that a busy schedule prevents regular yoga or meditation. Music is the most common coping method (63.6%). Asked about a 10–15 minute VR relaxation session described as free of side effects, 83.3% answer “yes, definitely” and 8.3% answer “maybe” if the price is under Rs. 5000. The findings yield design requirements, a system architecture, a session workflow and a protocol for comparing the gadget with guided breathing, meditation and relaxing music. That comparison is planned, not yet carried out: the prototype has not been tested with users, and the paper makes no claim of clinical effectiveness.